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Drug initiation after a first seizure decreases early seizure recurrence, but does not affect the long-term prognosis of developing epilepsy. Medication withdrawal after a period of seizure remission increases the risk of relapse, but the benefits of successful AED discontinuation may be substantial. In the end, the decision of whether to initiate treatment after a single seizure and whether to withdraw AED therapy in patients enjoying a prolonged period of seizure freedom should be made on an individual case basis, which balances the risk of seizure relapse and subsequent disability against the likely impact of medication-related physical, cognitive, and psychologic adverse effects. |
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anticonvulsants,discontinuation in seizure-free epileptics
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electroencephalogram,abnormalities of
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seizure,prognosis in childhood
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