Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Serial Proton MR Spectroscopy and Diffusion Imaging Findings in HIV-Related Herpes Simplex Encephalitis
AJNR 24:2015-2019, S�mann,P.G., et al, 2003
See this aricle in Pubmed

Article Abstract
We report the case of pathologically proved atypical herpes simplex encephalitis (HSE) in a 40-year-old male patient with AIDS who was followed up by MR imaging, which included diffusion-weighted imaging and proton MR spectroscopy (1H-MRS). MR revealed sparing of hippocampi and limbic cortices, necrosis of both cingulated gyri, and cerebellar involvement. Increased diffusivity and severe metabolic alterations were compatible with biopsy findings of necrotizing inflammation. Clinical recovery corresponded with partial metabolite and diffusion normalization and a myo-inositol increase that indicated evolving gliosis formation further corroborated by immunohistochemistry results. 1H-MRS and diffusion-weighted imaging may both support the diagnosis of HSE in patients with AIDS and help in the follow-up of necrotizing inflammation.
 
Related Tags
(click to filter results - removes previous filter)

acquired immunodeficiency syndrome
brain biopsy
cerebellar lesion
encephalitis
encephalitis,focal
herpes simplex encephalitis
herpes simplex encephalitis,atypical
herpes simplex virus infection,immunosuppressed patient
human immunodeficiency virus type 1
immunodeficiency
immunohistochemistry
immunosuppression
inclusion bodies
inclusion bodies,eosinophilic intranuclear
inclusion bodies,intranuclear
MRI
MRI,abnormal
MRI,diffusion weighted
MRS
neuropathology
opportunistic infection
polymerase chain reaction
polymerase chain reaction,false negative

Click Here to return To Results