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We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-) inhibitors for rheumatologic disorders. Although TNF- inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF- drugs and herpes simplex virus encephalitis has not been previously described. |
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acyclovir adalimumab adverse drug reaction atypical central nervous system,infection of complications encephalitis encephalitis,viral fever headache herpes simplex encephalitis herpes simplex encephalitis,atypical herpes simplex virus infection,immunosuppressed patient immunosuppression infection infliximab monoclonal antibodies MRI,abnormal MRI,false negative MRI,negative opportunistic infection opportunistic infection,CNS pleocytosis of cerebrospinal fluid polymerase chain reaction polymerase chain reaction,false negative psoriatic arthritis rheumatoid arthritis temporal lobe,lesion temporal lobe,lesion,bilateral treatment of neurologic disorder tumor necrosis factor inhibitor viral infection
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