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Late-onset chronic progressive panencephalitis developed in a 12-year-old boy with congenital rubella syndrome from whose brain rubella virus was isolated. Progressive dementia began at eight, and ataxia, choreiform movements, myoclonic seizures, and fine perimacular pigmentation appeared at 11 years of age. The cerebrospinal fluid was minimally pleocytotic and had a total protein of 156 mg per deciliter, of which 52 percent was gamma globulin. Electroencephalography demonstrated generalized medium and occasional high-voltage slowing without burst suppression. The antibody titer to rubella virus (hemagglutination inhibition) was 1:8192 in serum and 1:256 in cerebrospinal fluid. Antibody titer to measles virus (complement fixation) was less than 1:8 in serum. Microscopical study of biopsied brain tissue at the age of 11 disclosed panencephalitis similar to subacute sclerosing panencephalitis, but with perivascular deposits and without inclusion bodies. Rubella virus was isolated from the brain by cocultivation with CV-1 cells. |
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ataxic gait brain biopsy cerebrospinal fluid,gammaglobulin of cerebrospinal fluid,oligoclonal IgG in children chorea congenital infection,CNS dementia electroencephalogram,abnormalities of encephalitis encephalitis,viral gait disorder hearing loss intellectual deterioration maculopathy mimics movement disorder myoclonus,epilepsy pleocytosis of cerebrospinal fluid rubella encephalitis,progressive rubella syndrome rubella virus seizure serologic testing serologic testing of cerebrospinal fluid slow virus infection of CNS subacute sclerosing panencephalitis(S.S.P.E.)Dawson's disease viral infection virus,slow
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