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SMART Syndrome: A Late Reversible Complication after Radiation Therapy for Brain Tumours
J Neurol 258:1098-1104, Kerklaan, J.P.,et al, 2011
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Article Abstract
We report on four patients with reversible clinical and radiological features occurring years after radiation for brain tumours, suggestive for the so called SMART syndrome (stroke-like migraine attacks after radiation therapy). All four patients (males, age 36-60 years) had been treated with focal brain radiation for a primary brain tumour or with whole-brain radiation therapy for brain metastases. Ranging from 2 to 10 years following radiation therapy patients presented with headache and focal neurological deficits, suggestive for tumour recurrence. Two patients also presented with focal seizures. MRI demonstrated typical cortical swelling and contrast enhancement, primarily in the parieto-occipital region. On follow-up both clinical and MRI features improved spontaneously. Three patients eventually proved to have tumour recurrence.
 
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complications
gyrus,abnormal
headache
migraine
MRI,abnormal
MRI,cortical enhancement
MRI,disappearing lesion on
MRI,gyral enhancement
MRI,gyral swelling
neoplasm,primary intracerebral
neoplasm,primary of CNS-treatment of
neurologic examination,focal
radiation therapy,CNS treatment and complications with
seizure
SMART syndrome
strokelike episodes

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