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Zika Virus Associated with Microcephaly
NEJM 374: DOI:10.1056/NEJMoa1600651, Mlakar, J.,et al, 2016
See this aricle in Pubmed

Article Abstract
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America and the Caribbean. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with ZIKV. In this report, we describe the case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil. Ultrasonography performed at 29 weeks of gestation revealed microcephaly with calcifications in the fetal brain and placenta. After the mother requested termination of the pregnancy, a fetal autopsy was performed. Microencephaly (an abnormally small brain) was observed, with almost complete agyria, hydrocephalus, and multifocal dystrophic calcifications in the cortex and subcortical white matter, with associated cortical displacement and mild focal inflammation. ZIKV was found in the fetal brain tissue on reverse-transcriptase-polymerase-chain reaction (RT-PCR) assay, with consistent findings on electron microscopy. The complete genome of ZIKV was recovered from the fetal brain.
 
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arbovirus
arthralgia
Brazil
calcification,intracranial
caribbean
Central America
electron microscopy
epidemic
epidemiology of neurology
fever
flavivirus
Guillain Barre syndrome
headache
hydrocephalus
infection
intrauterine infection
intrauterine infection,viral
lissencephaly
microcephaly
molecular genetics
mosquito
muscle pain
neuropathology
polymerase chain reaction
rash
South America
ultrasonography,head
ultrasonography,head,fetus-neonate
viral infection
Zika virus infection

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