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Long-Term Preclinical Magnetic Resonance Imaging Alterations in Sporadic Creutzfeldt-Jakob Disease
Ann Neurol 80:629-632, Zanusso, G.,et al, 2016
See this aricle in Pubmed

Article Abstract
An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1.
 
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cerebral cortex
cerebrovascular accident,misdiagnosis
dementia
dementia,rapidly progressive
gait disorder
gyrus,abnormal
intellectual deterioration
Jakob-Creutzfeldt disease
Jakob-Creutzfeldt disease,unilateral
misdiagnosis
MRI,abnormal
MRI,diffusion weighted
MRI,serial
neuropathology
preclinical
prion disease
symmetric brain lesions

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