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An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. |
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cerebral cortex cerebrovascular accident,misdiagnosis dementia dementia,rapidly progressive gait disorder gyrus,abnormal intellectual deterioration Jakob-Creutzfeldt disease Jakob-Creutzfeldt disease,unilateral misdiagnosis MRI,abnormal MRI,diffusion weighted MRI,serial neuropathology preclinical prion disease symmetric brain lesions
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