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MERS is a novel clinic-radiological syndrome first described in Japan. A transient splenial lesion with reduced diffusion that appears as a high signal intensity in diffusion-weighted MRI is the main diagnostic feature. Rotavirus is one of the most common agents associated with MERS, although our knowledge only one previous case has been reported from Europe. The majority of patients appear to achieve full recovery following rotavirus-associated MERS, irrespective of treatment. This case, together with other published reports, supports the hypothesis that rotavirus-associated MERS is unlikely to be the result of direct viral invasion of the CNS. It has been suggested that MERS may caused by intra-myelinic axonal oedema or local inflammatory cell infiltration; however, the pathogenesis remains incompletely understood. |
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children corpus callosum corpus callosum,lesion of diarrhea differential diagnosis encephalopathy fever gastroenteritis gastrointestinal disease,neurologic complications headache hyponatremia level of consciousness,decreased mental status,abnormal MERS MRI,abnormal MRI,diffusion weighted MRI,disappearing lesion on nausea and vomiting prognosis reversible neurologic disorder reversible splenial lesion syndrome rotavirus seizure splenium of corpus callosum symmetric brain lesions viral infection viral infection,CNS
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