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Neurological Immune-Related Adverse Events of Ipilimumab
Pract Neurol 13:278-280, Bot, I.,et al, 2013
See this aricle in Pubmed

Article Abstract
Ipilimumab enhances the T lymphocyte mediated immune response to both tumour cells and healthy tissue, improving survival in patients with metastatic melanoma but also leads to more immune-related adverse events (irAEs) than previously used treatments, such as dacarbazine. We present three patients with neurological irAEs from ipilimumab treatment: Hypophysitis, meningitis and Guillain-Barr� syndrome. Once an irAE occurs, ipilimumab should be stopped and corticosteroids started. Usually, ipilimumab-induced irAE symptoms improve within days to weeks, but can be life-threatening if unrecognized.
 
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adverse drug reaction
carcinoma
complications
diabetes insipidus
fever
granulomatous hypophysitis
Guillain Barre syndrome
headache
iatrogenic neurologic disorders
immune checkpoint inhibitors
immune-related adverse events
immunomodulation
ipilimumab
melanoma,malignant
meningismus
meningitis
meningitis,drug induced
monoclonal antibodies
MRI,abnormal
myositis
neoplasm,metastatic to CNS
paresthesias
pituitary stalk
pituitary stalk,enlarged

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