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A total of 106 patients (63 males and 43 females:mean age, 44 years; range, 18-83 years) were included. Most common symptoms were changes in mental status, fever, headache, and seizure. HSV PCR was positive in 69% of patients tested, while brain involvement was detected on MRI in 95%. Acyclovir was started mostly within five days of main symptom and continued for greater than or equal to 14 days. Case fatality rate was 8%, while 69% of patients recovered with sequelae. Favorable prognosis was observed in 73% of patients. Multivariate analysis identified the duration of disease before hospital admission (odds ratio (OR) = 1.24) and the extent of brain involvement on MRI at the time of admission (OR=37.22) as two independent risk factors associated with poor prognosis. |
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acyclovir afebrile atypical coma complications confusion delay in diagnosis disability,neurological disorientation encephalitis,viral fever headache heralding manifestation herpes simplex encephalitis herpes simplex encephalitis,atypical herpes simplex encephalitis,diagnosis of herpes simplex encephalitis,prognosis of herpes simplex encephalitis,treatment of hypoglycorrhachia hyponatremia mental status,abnormal mortality MRI,abnormal neurologic disease,diagnoses of neurologic examination,focal pleocytosis of cerebrospinal fluid polymerase chain reaction polymerase chain reaction,false negative prognosis renal failure review article seizure temporal lobe,lesion,bilateral treatment of neurologic disorder
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