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Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke NEJM 380:1795-1803,1865, Ma, H.,et al, 2019 See this aricle in Pubmed Article Abstract Among the patients in this trial who had ischemic stroke and salvageable brain tissue, the use of alteplase between 4.5 and 9.0 hours after stroke onset or at the time the patients awoke with stroke symptoms resulted in a higher percentage of patients with no or minor neurologic deficits than the use of placebo. There were more cases of symptomatic cerebral hemorrhage in the alteplase group than in the placebo group.

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