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Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis
NEJM 380:2327-2340, Wilson, M.R.,et al, 2019
See this aricle in Pubmed
Article Abstract
Routine microbiologic testing is often insufficient to detect all neuroinvasive pathogens. In this study, metagenomic NGS of CSF obtained from patients with meningitis or encephalitis improved diagnosis of neurologic infections and provided actionable information in some cases.
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central nervous system,infection of
cerebrospinal fluid
cerebrospinal fluid,abnormal
encephalitis
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meningitis
meningitis,diagnosis
meningitis,viral
meningitis,viral etiology in
misdiagnosis
neurologic disease,diagnoses of
next-generation sequencing
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