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Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features
Ann Neurol 86:695-703, Johnson, T.P.,et al, 2019
See this aricle in Pubmed
Article Abstract
Dengue virus is the most common arbovirus worldwide and represents a significant public health concern. Infections with dengue virus are usually self-limiting, and chronic dengue infections have not been previously reported. Our findings suggest that dengue virus infections may persist in the central nervous system causing a panencephalitis and should be considered in patients with progressive dementia with extrapyramidal features in endemic regions or with relevant travel history. Furthermore, this work highlights the utility of comprehensive antibody profiling assays to aid in the diagnosis of encephalitis of unknown etiology.
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arbovirus
central nervous system,infection of
dementia
Dengue fever
encephalitis
endemic area
movement disorder
movement disorder,extrapyramidal
neuropathology
progressive neurologic disorder
travel history
viral infection
viral infection,CNS
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