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The SANAD II Study of the Effectiveness and Cost-Effectiveness of Valproate Versus Levetiracetam for Newly Diagnosed Generalised and Unclassifiable Epilepsy: An Open-Label, Non-Inferiority, Multicentre, Phase 4, Randomised Controlled Trial Lancet 397:1375-1386, Marson, A.,et al, 2021 See this aricle in Pubmed Article Abstract Compared with valproate, levetiracetam was found to be neither clinically effective nor cost-effective. For the girls and women of child-bearing potential, these results inform discussions about benefit and harm of avoiding valproate.

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