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Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction-Based Testing AJNR 40:1418-1421, Sarma, A.,et al, 2019 See this aricle in Pubmed Article Abstract Human parechovirus infection is an increasingly recognized cause of neonatal meningoencephalitis. We describe characteristic clinical features and brain MR imaging abnormalities of human parechovirus meningoencephalitis in 6 infants. When corroborated by increasingly available polymerase chain reaction-based testing of the CSF, the distinctive MR imaging appearance may yield a specific diagnosis that obviates costly and time-consuming further clinical evaluation. In our study, infants with human parechovirus presented in the first 35 days of life with seizures, irritability and sepsis. MR imaging consistently demonstrated low diffusivity within the thalami, corpus callosum, and subcortical white matter with a frontoparietal predominance. T1 and T2 shortening connoting white matter injury along the deep medullary veins suggests venous ischemia as an alternative potential pathogenetic mechanism to direct neuroaxonal injury.

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(click to filter results - removes previous filter) cerebrospinal fluid cerebrospinal fluid,cell count,normal children fever human parechovirus irritability leukoencephalopathy medullary streaks medullary veins meningoencephalitis MRI,abnormal MRI,diffusion weighted normal parechovirus encephalitis polymerase chain reaction rash seizure seizure,neonatal term infant white matter disease

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