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We studied the frequency,severity,and clinical correlations of cerebral amyloid angiopathy(CAA)in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains(25.6%)showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions.These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy(43.3%versus 23.0%; odds ratio=2.6,95%CI=1.1 to 6.2).High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia.Our findings suggest that factors contributing to non-AD-related vascular pathology(e.g.,atherosclerosis)may play a role in amyloid deposition in cerebral vessels in AD. |
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