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We prospectively evaluated 47 children with neurofibromatosis to determine whether the previously reported high signals on magnetic resonance imaging (MRI)(prolonged T2)correlated with CT,brainstem auditory evoked responses (BAER),EEG,clinical examinations,cognitive abilities,or seizure disorder. Thirty percent of children had a history of seizures and 70%had either learning disabilities or mental retardation.Overall 74%had an abnormal MRI examination.Sixty-two percent had high signals(prolonged T2)on T2-weighted images.Abnormal signals were located primarily in the basal ganglia, brainstem,and cerebellum.Twenty-five percent of patients had abnormal EEGs,28%had abnormal CTs,and 27%had abnormal BAER examinations.The abnormal signals on MRI did not consistently relate to findings of CT, BAER,EEG,school placement or clinical examination.The abnormal signals presumably reflect areas of abnormal brain parenchyma,either hamartomas, heterotopias,or local areas of brain dysplasia. |
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auditory evoked brainstem potentials
basal ganglia,lesion of
brainstem,lesion of
CAT scan
CAT scan,abnormal
cerebellum,disease of
globus pallidus,lesion of
MRI
MRI,abnormal
MRI,CAT scan compared to
neurofibromatosis 1
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