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We studied the serum antibody titers to Epstein-Barr virus(EBV)in 11 patients with HTLV-I-associated myelopathy(HAM).HAM patients showed significant increases in IgG antibodies to EBV-capsid antigen(VCA)and early antigen(EA)and in VCA-specific IgA compared with 25 seronegative subjects.However,there were no significant differences in antibodies to EBV-nuclear antigen(EBNA)or to other viruses between the two groups.In HAM patients,altered antibody responses occurred specifically to EBV- associated antigens,not to other viruses. |
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