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Correlation Between Cranial CT Scans at Diagnosis in Children with Acute Lymphoblastic Leukaemia and CNS Relapse Lancet 2:1212-1214, Jankovic,M.,et al, 1988 See this aricle in Pubmed Article Abstract 145 children with acute lymphoblastic leukaemia(ALL)were evaluated over a period of 3 years in a multicentre study in which serial cranial computed tomographic(CT)scans of the brain were done.All patients were symptom- free.CT scans were graded as normal,borderline(slight or moderate cerebral atrophy)or pathological(severe cerebral atrophy).62%(90/145)of children had CT scan abnormalities at diagnosis.After a median follow-up of 24 months(range 6-36)12 of 108 evaluated patients had central nervous system (CNS)relapses(6 isolated relapses and 6 combined with relapse at another site).All patients with CNS relapse had an abnormal CT scan at diagnosis(8 pathological and 4 borderline).No relapses were observed among the 42 patients with a normal cranial CT scan at diagnosis.A significantly higher proportion of severe cerebral atrophy,both following CNS prophylaxis and after the discontinuation of treatment,was found among patients with a borderline CT scan at diagnosis than among patients with a normal CT scan at diagnosis.Thus an abnormal cranial CT scan at diagnosis in children with ALL seems to have prognostic significance.

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(click to filter results - removes previous filter) CAT scan CAT scan,abnormal leukemia leukemia,neurologic findings assoc.with prognosis

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