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Detection of Human T-Cell Leukemia/Lymphoma Virus Type I in a Transfusion Recipient with Chronic Myelopathy Neurol 39:841-844, Saxton,E.H.,et al, 1989 See this aricle in Pubmed Article Abstract A white man with a progressive spastic paraparesis that began 15 months after sustaining severe trauma in a motor vehicle accident was positive for antibodies to human T-lymphotropic virus type I(HTLV-I)by enzyme- linked immunosorbent assay.Serum antibody to HTLV-I was confirmed by Western blot and radioimmunoprecipitation assay.We detected specific proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction.Because the incidence of HTLV-I is generally restricted to Southern Japan and Caribbean black populations,the most likely source of HTLV-I infection in this patient was multiple intraoperative blood transfusions.The relatively short interval between transfusion and development of HTLV-I-associated myelopathy is consistent with the more rapid evolution of this clinical syndrome compared with adult T-cell leukemia.

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(click to filter results - removes previous filter) blood transfusion human T-lymphotropic virus type I(HTLV-I) MRI MRI,abnormal myelopathy myelopathy,chronic progressive paraparesis,spastic

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