Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

The Effect of Dietary Protein on the Efficacy of L-Dopa:A Double-Blind Study
Neurol 39:549-552, Tsui,J.K.,et al, 1989
See this aricle in Pubmed

Article Abstract
We randomly placed 10 parkinsonian patients on high-and low-protein diets that tasted and looked alike,each for 1 week.All patients were taking L- dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged.A"blind"physician recorded the modified Columbia scores,objective measurements of rigidity,movement velocity,and pegboard tests three times a day for 5 days during each week.The patients recorded fluctuations hour to hour.We measured serial blood L-dopa levels on day 4 of each week.Performance was significantly better while the patients were on low-protein diets.These results did not correlate with blood L-dopa levels,which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of"off"hours.Thus,high dietary protein probably affects the efficacy of L-dopa at a central level.
 
Related Tags
(click to filter results - removes previous filter)

diet
L-dopa
L-dopa,plasma concentration
Parkinson disease
Parkinson disease,diet restricted in protein
Parkinson disease,on-off phenomena in
Parkinson disease,treatment of
treatment of neurologic disorder

Click Here to return To Results