Neurology Specific Literature Search   
Click Here to return To Results


Increased Plasma Methylmalonic Acid Level Does Not Predict Clinical Manifestations of Vitamin B12 Deficiency
Arch Int Med 161:1534-1541, Hvas,A.,et al, 2001
See this aricle in Pubmed

Article Abstract
The prevalence of vitamin B12 deficiency, defined as an elevated concentrations of plasma methylmalonic acid (P-MMA), has been estimated to be 15% to 44% in the elderly. However, we do not know whether an increased P-MMA level actually indi cates or predicts a clinical condition in need of treatment. An increased level of P-MMA did not predict a further increase with time and clinical manifestations related to vitamin B12 deficiency. We therefore challenge the use of an increased P-MMA con centration as the only marker for diagnosis of vitamin B12 deficiency.
Related Tags
(click to filter results - removes previous filter)

B 12 deficiency
controversies in neurology
methylmalonic acid,serum
old age,neurology of

Click Here to return To Results