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Juvenile Myoclonic Epilepsy:An Autosomal Recessive Disease Ann Neurol 25:440-443, Panayiotopoulos,C.P.&Obeid,T., 1989 See this aricle in Pubmed Article Abstract We undertook genetic study of patients with juvenile myoclonic epilepsy (JME)from 17 families.There was a mean of 8 children in each subship. Siblings were affected in 8 sibships,and some families had more than 2 members affected by JME.Half-siblings and parental involvement were found in only 1 sibship each.The segregation ratio was 0.123 but increased to 0. 18 with correction for age on onset.Parental consanguinity was found in 9 (45%)of the sibships.The evidence establishes an autosomal recessive mode of inheritance for JME.

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(click to filter results - removes previous filter) consanguinity genetic neurologic disorders juvenile myoclonus epilepsy myoclonus,epilepsy seizure seizure,familial

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