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By studying 3,408 consecutive autopsied elderly patients,we found that two thirds of the 132 massive cerebral infarctions(86)were embolic,of cardiac origin.Embolic infarction associated with nonvalvular atrial fibrillation was seen in 48 cases(36%),half due to the first stroke.Embolic infarction associated with heart diseases other than nonvalvular atrial fibrillation was seen in 23 cases(17%),and that from nonbacterial thrombotic endocarditis was seen in 15 cases(11%).Thrombotic infarction or infarction of nonembolic cardiac origin was found in only 39 cases(30%).Of 56 patients with fatal massive cerebral infarction who died=2 weeks after their stroke,25(45%)had embolic strokes associated with nonvalvular atrial fibrillation.Our study shows that nonvalvular atrial fibrillation is a very important cause of fatal massive cerebral infarction in the elderly. |
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atrial fibrillation cerebral embolism cerebral embolism,cardiac origin cerebrovascular accident cerebrovascular accident,etiology cerebrovascular accident,prevention of cerebrovascular accident,prognosis in embolism mortality old age,neurology of prognosis
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