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Significant neurotoxicity including seizures,encephalopathy and coma may complicate the use of cyclosporin A(CyA).Two patients are described, receiving CyA,who presented with abnormal behaviour,stupor,focal motor activity and were shown to be in complex partial status epilepticus(CPSE). Abnormalities of behaviour and/or stupor in patients receiving CyA may be a manifestation of CPSE.Patients receiving CyA who develop an encephalopathy should have electroencephalography performed at the time of the abnormal behaviour. |
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