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Early pathological abnormalities in human immunodeficiency virus(HIV-1)- related dementia have not been well documented.We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV-1-related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study.Within 4 months he died of massive epistaxis,and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation,multinucleated giant cells,and brain atrophy. |
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