|
|
|
|
Among 22 patients with human T-lymphotropic virus type I(HTLV-I)- associated chronic progressive myelopathy,agarose isoelectric focusing (AIF)revealed oligoclonal IgG bands in 21:in 3 in CSF only;in 11 in CSF and to some extent in serum;and in 7,identical patterns on CSF and serum. By immunoblot after AIF of CSF and serum,we observed bands of anti-HTLV-I IgG antibodies in 19 patients:in 5 in CSF only;in 9 in CSF and partly in serum;and in 5,identical in CSF and serum.Oligoclonal anti-HTLV-I antigen, practically all oligoclonal HTLV-I-specific IgG antibody activity was abolished,while the oligoclonal pattern of total IgG was affected only to a minor extent.Alongside with HTLV-I-specific oligoclonal B cell response, HTLV-I myelopathy is regularly accompanied by production of oligoclonal IgG of unknown antibody specificities. |
|