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Clozapine in the Treatment of Parkinsonian Patients with Dopaminomimetic Psychosis
Neurol 40:832-834, Wolters,E.Ch.,et al, 1990
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Article Abstract
In a double-blind placebo-controlled study,we evaluated the effects of clozapine(75 to 250 mg/day,mean 170.8)on dopaminomimetic psychosis and parkinsonian disability.Clozapine prevented deterioration of psychosis during the increase of dopaminomimetics in the 3 patients who completed the study.Worsening of parkinsonism occurred in 3 of the 6 patients.In the dosage used,clozapine's usefulness was limited by its propensity to produce sedation,confusion,and increased parkinsonism.
 
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adverse drug reaction
clozapine
movement disorder,drug induced
Parkinson disease
Parkinson disease,drug induced
psychosis
treatment of neurologic disorder

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