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Regional cerebral blood flow(rCBF)was evaluated quantitatively by 99mTc hexamethyl propyleneamine oxime and single photon emission CT(SPECT)during the interictal phase in 52 patients with focal epilepsy.The results were compared with those obtained by electroencephalography(EEG),CT,and magnetic resonance(MR)imaging.Twenty-four of the 52 patients had one area of local hypoperfusion whereas 7 patients showed an area of local lyperperfusion.In 20 of the 52 patients,both reduced and elevated rCBF values were found.One patient had a normal perfusion pattern.The SPECT findings correlated well with the foci shown by EEG,both with regard to the sides affected and the locations of the regions of altered perfusion. The MR images showed focal lesions in only approximately one-half of the patients examined,and CT in even fewer.newabs Al19R We evaluated the association between alcohol consumption and carotid atherosclerosis in 261 consecutive patients>50 years old admitted to our community-based primary- care center with first ischemic stroke;their characteristics were entered into a computerized data bank(Lausanne Stroke Registry).Reported regular alcohol consumption was compared with the presence and severity of internal carotid artery disease as assessed by duplex scanning with spectral analysis of the Doppler signal and real-time B-mode imaging at the level of the carotid bifurcation.We found an inverse linear relation between light-to-moderate alcohol intake(=4 standard drinks/day)and severity of internal carotid artery stenosis.No conclusion could be drawn for heavier drinkers because there were too few.A logistic regression model showed that hypertension,cigarette smoking,and age in men and diabetes mellitus and cigarette smoking in women strongly counterbalanced the potential benefit of alcohol consumption.Although regular alcohol drinking cannot be advocated on the basis of our findings,light-to- moderate consumption of alcohol is the first factor to be inversely associated with extracranial carotid atherosclerosis in symptomatic patients with cerebrovascular disease. |
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electroencephalogram electroencephalogram,abnormalities of MRI MRI,abnormal seizure seizure,focal single photon emission computed tomography
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