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Gabapentin in Partial Epilepsy UK Gabapentin Study Group, Lancet 335:1114-11171990., , 1990 See this aricle in Pubmed Article Abstract Gabapentin is an analogue of aminobutyric acid(GABA)which had anticonvulsant properties in animals.In a multicentre,doulbe-blind, placebo-controlled,parallel-group study of 1200 mg/day with drug-resistant partial epilepsy,25%of patients who received gabapentin had the number of partial seizures at least halved,compared with 9.8%of patients given placebo.The median reduction in partial seizure frequency during 12 weeks' treatment was 29.2%with gabapentin compared with 12.5%with placebo.The mean adjusted response ratio for gabapentin(-0:192)was significantly better than the ratio of-0:060 for placebo by analysis of variance.62%of patients who received gabapentin reported mostly mild or moderate adverse effects compared with 41%on placebo;no interactions were observed between gabapentin and other standard anticonvulsants.Gabapentin is an effective additional treatment for patients with partial epilepsy refractory to standard therapy,is fairly well tolerated,and appears to have a favourable efficacy-to-toxicity ratio.

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