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The Physicians'Health Study is a randomized,double-blind,placebo- controlled trial that studied low-dose aspirin(325 mg every other day) therapy among 22071 US male physicians aged 40 to 48 years.Annual follow- up questionnaires requested information on the occurrence of numerous medical conditions in including migraine.At the end of 60 months,morbidity follow was 99.7%complete,and the reported consumption of aspirin or other platelet-active drugs was 86%in the aspirin group and 14%in the placebo group.Of those randomized to aspirin,661(6.0%)reported migraine at some time after randomization,as compared with 818(7.4%)of those allocated to the placebo group,representing a statistically significant 20%reduction in recurrence rate.The rate of self-report of ordinary headache was similar in the two groups.These data indicate that migraine is mediated,at least in part,by the effects of platelets and suggest that low-dose aspirin should be considered for prophylaxis among those with a history of established migraine. |
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