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Emergence of Recreational Drug Abuse as a Major Risk Factor for Stroke in Young Adults Ann Int Med 113:821-827, Kaku,D.A.&Lowenstein,D.H., 1990 See this aricle in Pubmed Article Abstract Seventy-three patients with stroke(34%)were drug abusers compared with 18 (8%)of the controls.In 47 patients with stroke,temporal proximity of drug administration(n=34)or infectious endocarditis(n=13)suggested a direct association between drug abuse and stroke.After controlling for other identifiable stroke risk factors,the estimated relative risk for stroke among drug abusers compared with that among non-drug abusers was 6.5(95% CI,3.1 to 13.6)and this increased to 49.4(CI,6.4 to 379.0)for those patients whose symptoms began within 6 hours of drug administration.Among patients less than 35 years of age,drug abuse was the most commonly identified potential predisposing condition(47%),and it was the only condition with a significantly elevated relative risk for stroke(11.7;CI, 3.2 to 42.5).Further,a substantial rise in the proportion of drug-related strokes was observed in the last 3 years of the study(31%in 1986 to 1988, compared with 15%in 1979 to 1985,p=0.008).Cocaine,especially recently,was the drug used most frequently in drug-related strokes.

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