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Digitalis has been shown to reverse conduction block in demyelinated nerve fibers in experimental animals.In the search for a symptomatic treatment of multiple sclerosis,digozin(0.02 mg per kilogram of body weight)was given intravenously to 7 patients with probable or clinically definite multiple sclerosis.All of these patients had temperature-dependent symptoms.In 3 patients,improvement of clinical deficits was observed concurrent with significant changes in evoked potential findings.Digitalis derivatives may be useful in ameliorating symptoms in selected patients with multiple sclerosis. |
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