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In the not too distant past Alzheimer's disease was considered sufficiently ubiquitous to permit its diagnosis in the elderly demented, once cerebrovascular disease,cerebral trauma and alcohol abuse had been excluded.An attempt to use inclusion rather than exclusion criteria for" probable"or"possible"Alzheimer's disease is contained in the Diagnostic Statistical Manual III.The latter now serves as holy writ in the search for clinical confirmation of Alzheimer's disease to the neglect of forms of cerebral atrophy which may be clinically and pathologically distinct from Alzheimer's disease and yet meet its descriptive psychiatric diagnostic criteria.The last few years have witnessed a directional change in the investigation of primary cerebral atrophy with qualitative neuropsychological analysis of clinical syndromes allied to more functional brain imaging techniques and histologic verification.Some new and distinct cerebral disorders have emerged,which are much more common than previously supposed and those reviewed here comprise dementia frontal-lobe type(DFT),DFT and motor neuron disease(MND),lobar atrophy and diffuse Lewy body disease. |
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apraxia
cerebral cortical atrophy
dementia
dementia,frontal lobe type
frontal lobe,atrophy
frontal lobe,behavior with disease of
frontal lobe,lesion of
Lewy body disease,diffuse
lobar atrophy
motor neuron disease
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