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N-Isopropyl-p- (123I) Iodoamphetamine SPECT in MELAS Syndrome:Comparison with CT & MR Imaging J Comput Assist Tomogr 15:77-82, Satoh,M.,et al, 1991 See this aricle in Pubmed Article Abstract Regional cerebral perfusion was studied in three patients with the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes(MELAS)syndrome,using single photon emission computed tomography (SPECT)with N-isopropyl-p[123I]iodoamphetamine(IMP).Accumulation of the tracer was relatively decreased in the parietooccipital regions and also in the frontotemporal regions after stroke-like episodes.However, quantitative regional cerebral blood flow(rCBF)measurement showed that rCBF was relatively well preserved even at these sites,and a hyperemic state was observed at the sites of normal accumulation.IMP SPECT may be useful in the diagnosis and assessment of the progress of the MELAS syndrome.

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(click to filter results - removes previous filter) CAT scan CAT scan,abnormal MELAS syndrome mitochondrial encephalomyopathy MRI MRI,abnormal MRI,CAT scan compared to single photon emission computed tomography

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