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Muscle biopsies of 4 patients with the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan showed lymphocytic infiltrates with occasional eosinophils largely restricted to interstitial fibrous tissue and perivascular areas.There was inflammation and fibrosis of muscle spindle capsules in 3 patients.In the 2 sickest patients,there was profound muscle atrophy,affecting both muscle fiber types. |
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