Click Here to return To Results

 

Nystagmus of Pelizaeus-Merzbacher Disease Arch Neurol 48:87-91, Trobe,J.D.,et al, 1991 See this aricle in Pubmed Article Abstract Magnetic search-coil oculography of three brothers with clinically diagnosed Pelizaeus-Merzbacher disease disclosed the presence of binocular elliptical pendular nystagmus in two patients in whom the waveform of the nystagmus was not obvious on inspection.This study,the first reported application of high-resolution oculography to Pelizaeus-Merzbacher disease,also demonstrated primary position upbeat nystagmus in all three patients.The importance of finding this combination of elliptical pendular and upbeat nystagmus is that it is not described in any other childhood neurodegenerative states and,in combination with supportive clinical history and magnetic resonance imaging,may be so characteristic of Pelizaeus-Merzbacher disease that a strong presumptive diagnosis can be made.

Related Tags

(click to filter results - removes previous filter) electronystagmography genetic neurologic disorders head nodding leukodystrophy MRI,abnormal nystagmus nystagmus,pendular nystagmus,primary position of gaze nystagmus,upbeating-in primary position of gaze Pelizaeus Merzbacher

Click Here to return To Results