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JC Virus Detection by In Situ Hybridization in Brain Tissue from Elderly Patients Ann Neurol 29:428-432, Mori,M.,et al, 1991 See this aricle in Pubmed Article Abstract Brains from 10 patients aged 68 to 96 years at time of death were studied for JC viral DNA and common papovaviral capsid protein.In situ hybridization to JC viral DNA was performed by affinity cytochemistry using a biotinylated fragment of JC viral DNA.Immunohistochemistry was performed on brain tissue by the avidin DH-biotinylated horseradish peroxidase technique using polyclonal antibody raised against the papovaviral capsid protein.Viral protein and DNA were detected in 4 of 10 patients.JC virus may be present in the brains of aged patients more frequently than previously suspected.

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(click to filter results - removes previous filter) immunohistochemistry immunoperoxidase staining in situ hybridization JC virus old age,neurology of papovavirus slow virus infection of CNS viral infection viral infection,CNS

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