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Using a noninvasive portable blood pressure recorder,we compared 24-hour variations of blood pressure among 1)35 patients with Binswanger-type dementia,2)43 with lacunar-type dementia,3)26 with a single lacunar stroke,and 4)30 controls.Each group was divided into antihypertensive- treated and-untreated subgroups.Among the untreated subgroups,patients with Binswanger-type dementia had significantly greater 24-hour mean systolic blood pressures,24-hour systolic blood pressure standard deviations,and maximal systolic blood pressure variations than the controls(p<0.05).Among the treated patients,blood pressure variability increased similarly in all subgroups with cerebrovascular lesions compared with the controls(p<0.05).The nocturnal blood pressure decreases seen in the controls were absent among both untreated and treated patients with Binswanger-or lacunar-type dementia(p<0.05).Our results suggest the importance of hypertension,short-term variations in blood pressure,and a sustained nighttime elevation of blood pressure for the pathogenesis of both Binswanger-type and lacunar-type dementia in patients receiving antihypertensive medication. |
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Binswanger disease blood pressure CAT scan CAT scan,abnormal dementia dementia,cerebrovascular disease causing hypertension hypertension,cerebrovascular disease with
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