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We describe 10 infants with developmental delay and congenital cerebral anomalies who were found to have had in utero exposure to vasoactive drugs.Nine infants had ophthalmological abnormalities;these included strabismus,nystagmus,and/or hypoplastic optic discs.Six mothers used cocaine,one used cocaine and heroin,one used only heroin,one used amphetamine,and one used phenylpropanolamine.Each of these cerebral anomalies(agenesis of the corpus callosum,septo-optic dysplasia, schizencephaly,hydranencephaly,congenital hydrocephalus,porencephaly,and cerebral infarctions)can be attributed to insults at different stages of development.There appears to be a relationship between the time of prenatal drug exposure and the type of cerebral anomaly,evoking malformations,disruptions,or fetal strokes.Since many or possibly all of these anomalies are thought to have a vascular origin,it seems appropriate to implicate prenatal exposure to vasoactive drugs. |
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