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Frontal Lobe Degeneration:Clinical, Neuropsychologicaland SPECT Characteristics
Neurol 41:1374-1382, Miller,B.L.,et al, 1991
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Article Abstract
The clinical,neuropsychological,and cerebral blood flow characteristics of eight patients with frontal lobe degeneration(FLD)were studied.Social withdrawal and behavioral disinhibition were the earliest and most common clinical presentations,and psychiatric symptoms typically preceded the onset of dementia by several years.Neuropsychological testing showed selective impairment of frontal and memory tasks with relative sparing of attention,language,and visuospatial skills.Single-photon emission computerized tomography demonstrated frontal and temporal hypoperfusion with relative sparing of parietal and occipital blood flow.Previous studies suggest that the neuropathologic findings in patients with FLD are varied;some demonstrate frontal gliosis,neuronal loss,and Pick bodies while others show only gliosis and neuronal loss.
 
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behavioral disorder
dementia
dementia,frontal lobe type
depression
frontal lobe,atrophy
frontal lobe,behavior with disease of
irritability
judgement,impaired
lobar atrophy
personality change
psychiatric problems in neurologic disorders
psychological testing
psychosis
release phenomena
single photon emission computed tomography
wandering
withdrawal,social

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