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We evaluated 23 families with familial amyotrophic lateral sclerosis for linkage of the gene causing this disease to four DNA markers on the long arm of chromosome 21.Multipoint linkage analyses demonstrated linkage between the gene and these markers.The maximum lod score-5.03-was obtained 10 centimorgans distal(telemetric)to the DNA marker D21S58.There was a significant probability(P<0.0001)of genetic-locus heterogeneity in the families.Conclusions.The localization of a gene causing familial amyotrophic lateral sclerosis provides a means of isolating this gene and studying its function.Insight gained from understanding the function of this gene may be applicable to the design of rational therapy for both the familial and sporadic forms of the disease. |
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