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One hundred neonates determined prospectively to be at risk for neurologic handicap underwent magnetic resonance imaging with a high-field(1.5 T) image.Thirty-three demonstrated a total of 37 lesions consistent with hypoxic-ischemic encephalopathy,including periventricular leukomalacia(n= 12),basal ganglia hemorrhage(n=5),multicystic encephalomalacia(n=5),and focal parenchymal hemorrhage(n=15).Diagnoses by ultrsonography and computed tomography were compared with those by magnetic resonance imaging in 29 and 17 infants,respectively.Ultrasonography detected 79%of lesions demonstrated by magnetic resonance imaging whereas computed tomography detected only 41%.Periventricular leukomalacia was seen most often in preterm infants and focal parenchymal hemorrhage occurred at all gestational ages.Basal ganglia hemorrhage and multicystic encephalomalacia were strongly associated with histories of perinatal asphyxia,seizures,and early abnormal neurologic status.All infants with basal ganglia hemorrhage (5/5)and multicystic encephalomalacia(5/5)and the majority with periventricular leukomalacia(9/12)and focal parenchymal hemorrhages(9/15) had developmental abnormalities at discharge. |
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basal ganglia,hemorrhage
developmental disability
disability,neurological
encephalomalacia
hypoxia
hypoxia,newborn
hypoxic encephalopathy
intracerebral hemorrhage
MRI
MRI,abnormal
MRI,CAT scan compared to
neurologic examination
newborn,evaluation of
periventricular leukomalacia
premature infant
prognosis
seizure
seizure,neonatal
ultrasonography
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