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We report 12 adults with seizures associated with serum theophylline levels between 14 and 35 mg/l.The seizures were frequently prolonged,and outcome was generally poor with eight deaths.Although we did not identify comparable control groups,possible risk factors for serious outcome in theophylline-associated seizures were age,previous brain injury or disease,severe pulmonary disease,and possibly low serum albumin level.In patients with these risk factors,serum theophylline levels should be maintained below 10 to 15 mg/l. |
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