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A double-blind,placebo-controlled trial was set up to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis(TE)in HIV- infected patients at risk of the disorder.Interim analysis showed that clindamycin-treated patients were 4.4(95%confidence interval 1.3-15.2) times more likely to experience an adverse effect that necessitated withdrawal of the study drug than those who received placebo.Diarrhoea and rash were reported in 16(31%)and 11(21%),respectively,of 52 patients treated with clindamycin(300 mg twice daily)compared with 2(6:;p=0.06)and none(p=0.01)of the 32 placebo-treated patients.The clindamycin arm of the trial was prematurely terminated,although recruitment to the pyrimethamine arm continues. |
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