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At a mean follow-up of 11.9 months,there was a significant reduction in stroke or crescendo transient ischemic attacks in patients who received carotid endarterectomy(7.7%)compared with nonsurgical patients(19.4%),or an absolute risk reduction of 11.7%(P=.011).The benefit of surgery was more profound in patients with internal carotid artery stenosis greater than 70%(absolute risk reduction 17.7%,P=.004).The benefit of surgery was apparent within 2 months after randomization,and only one stroke was noted in the surgical group beyond the 30-day perioperative period.Conclusions: For a selected cohort of men with symptoms of cerebral or retinal ischemia in the distribution of a high-grade internal carotid artery stenosis, carotid endarterectomy can effectively reduce the risk of subsequent ipsilateral cerebral ischemia.The risk of cerebral ischemia in this subgroup of patients is considerably higher than previously estimated. |
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carotid artery
carotid artery disease
carotid artery stenosis
cerebrovascular accident
cerebrovascular accident,prevention of
cerebrovascular accident,surgical treatment of
cerebrovascular disease,risk factors in
cerebrovascular disease,surgical treatment of
endarterectomy,carotid
endarterectomy,carotid-indications for
retinal ischemia
treatment of neurologic disorder
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