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Endotoxin Concentr in CSF Correlate with Clin Severity & Neuro Outcome of H Flu Type B Meningitis Am J Dis Child 145:1099-1103, Mertsola,J.,et al, 1991 See this aricle in Pubmed Article Abstract Endotoxin concentrations were measure din paired samples of cerebrospinal fluid from 38 patients with Haemophilus influenzae type b meningitis.On admission,the median concentration of endotoxin in cerebrospinal fluid was 104 ng/mL and decreased rapidly in follow-up samples.From 17 to 48 hours after admission,50%of the patients had concentrations of less than 1 ng/ ml.Endotoxin concentrations correlated significantly with concentrations of interleukin 1B,protein,and glucose in cerebrospinal fluid,duration of secondary fever,and neurologic abnormalities during hospitalization and on follow-up examinations.Twenty-eight percent of patients with endotoxin concentrations of 100 ng/mL or more on admission had long-term complications,compared with none of those with lower endotoxin concentrations(relative risk,2.31:95%confidence interval,1.53 to 3.48). These results indicate that quantitation of endotoxin in cerebrospinal fluid could be a valuable aid in identifying those children at increased risk of complications during Haemophilus influenzae type b meningitis and provide additional evidence that the Haemophilus influenzae type b meningitis lipo-oligosaccharide is important in the pathogenesis of meningitis.

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(click to filter results - removes previous filter) cerebrospinal fluid cerebrospinal fluid,abnormal endotoxin meningitis meningitis,bacterial meningitis,children meningitis,hemophilus influenza meningitis,neurologic aspects and complications of prognosis

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