|
|
|
|
|
Click Here to return To Results
|
|
|
|
Over a 22-month period,we investigated optic and otic toxicity accompanying intraarterial cisplatin therapy.Baseline and serial neurologic and ophthalmologic examinations,visual evoked potentials,and brainstem auditory evoked potentials were performed in six patients,aged 37 to 53 years.Patients received infraophthalmic intra-arterial cisplatin (60 mg/m2)every month for three to 10 treatments(mean,six treatments).Five of the six patients had progressive optic toxicity.In two patients,the visual evoked potential prolongation preceded acuity loss by at least 4 months.Two patients had evidence of otic toxicity by either brainstem auditory evoked potential or click threshold and brain-stem auditory evoked potential.Intra-arterial cisplatin neurotoxicity may be significant in patients with already limited survival.Visual evoked potential and brain-stem auditory evoked potential should be used to monitor patients receiving potentially neurotoxic therapy. |
|
(click to filter results - removes previous filter)
auditory evoked brainstem potentials
chemotherapy,CNS treatment and complications with
chemotherapy,intra-arterial
cis-platinum
cranial neuropathy
cranial neuropathy,multiple
evoked potentials
hearing loss
neurotoxic
optic neuropathy
optic neuropathy,toxic
ototoxicity
visual acuity,decreased
visual evoked response
visual loss
|
Click Here to return To Results
|
|