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Hyponatraemia and Death or Permanent Brain Damage in Healthy Children
BMJ 304:1218-1222, Arieff,A.I.,et al, 1992
See this aricle in Pubmed

Article Abstract
By retrospective evaluation the incidence of postoperative hyponatraemia among 24412 patients was 0.34%(83 cases)and mortality of those afflicted was 8.4%(seven deaths).In the prospective population the serum sodium concentration on admission was 138(DS 2)mmol/l.From three to 120 inpatient hours after hypotonic fluid administration patients developed progressive lethargy,headache,nausea,and emesis with an explosive onset of respiratory arrest.At the time serum sodium concentration was 115(7)mmol/l and arterial oxygen tension 6(1.5)kPa.The hyponatraemia was primarily caused by extrarenal loss of electrolytes with replacement by hypotonic fluids. All 16 patients had cerebral oedema detected at either radiological or postmortem examination.All 15 patients not treated for their hyponatraemia in a timely manner either died or were permanently incapacitated by brain damage.The only patient treated in a timely manner was alive but mentally retarded.Conclusions-Symptomatic hyponatraemia can result in a high morbidity in children of both genders,which is due in large part to inadequate brain adaption and lack of timely treatment.
 
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cerebral edema
encephalopathy
headache
hyponatremia
hyponatremic encephalopathy
lethargy
mortality
nausea and vomiting
neurologic complications of,surgery
neuropathology
postoperative neurologic complications
prognosis
respiratory arrest
treatment of neurologic disorder
uncal herniation

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