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Low Cerebrospinal Fluid Concentration of Free Gamma-Aminobutyric Acid in Startle Disease
Lancet 340:80-81, Dubowitz,L.M.S.,et al, 1992
See this aricle in Pubmed

Article Abstract
The pathophysiology of startle disease(hyperekplexia)is unknown. Hyperactivity of the brainstem reticular formation has been suggested as a cause.We report a newborn infant with classic features of startle disease in whom cerebrospinal fluid(CSF)concentrations of gamma-aminobutyric acid (GABA)were substantially lower than normal during the first weeks of life. She improved greatly on clonazepam treatment.We suggest that the signs of this disorder may be due to a genetic defect or to delayed maturation resulting in low CSF GABA.
 
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cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrospinal fluid,gamma amino butyric acid
clonazepam
gamma amino butyric acid
hyperekplexia
startle reaction
treatment of neurologic disorder

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